Acta radiologica: diagnosis
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Acta Radiol Diagn (Stockh) · Mar 1986
Videodensitometry and chest radiography in the evaluation of pulmonary blood flow and pulmonary oedema in a porcine model of early adult respiratory distress syndrome.
The adult respiratory distress syndrome was induced in pigs (n = 11) by a continuous infusion of E. coli endotoxin in order to evaluate the use of radiographic videodensitometry and chest radiography for assessment of pulmonary circulation and pulmonary oedema. A further aim was to determine the effect of an ionic contrast medium, Urografin 60%, on extravascular lung water (EVLW). The infusion resulted in a decline in arterial oxygen tension. ⋯ Pleural effusion developed in 4 animals. Injection of Urografin 60%, 1 ml X kg-1, caused a slight but significant decrease in EVLW. We propose that at this concentration and dosage the contrast medium acts mainly as an osmotic diuretic.