Journal of medicine
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Journal of medicine · Jan 1999
Comparative Study Clinical Trial Controlled Clinical TrialSerum thrombomodulin as a prognostic marker of disseminated intravascular coagulation.
Disseminated intra-vascular coagulation (DIC) is associated with severe bleeding tendency and organ failure, the extent of which is thought to be related to the prognosis of DIC patients. Thrombomodulin (TM) is a high-affinity thrombin receptor on vascular endothelial cells. ⋯ The significant elevation of circulating TM in nonsurvivors with DIC compared with survived patients with DIC(TM 3.1+/-1.52 vs 8.1+/-3.89 FU/ml), as well as FDP (12.9+/-12.12 vs 49.8+/-55.42 microg/ml) but the levels of FDP were not different between the two groups. The measurement of circulating TM was a relatively good prognostic marker of patients with DIC.
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Journal of medicine · Jan 1999
Assessment of inflammatory mediators in patients with generalized peritonitis.
We investigated the pathology and the involvement of type II phospholipase A2 (type II PLA2), inflammatory cytokines, nitrite/nitrate (NOx), and endotoxin in generalized peritonitis. All of the factors except endotoxin were higher in the non-surviving group, the shock group, and the multiple organ dysfunction syndrome (MODS) group than in the surviving group, the shock-free group, and the MODS-free group, respectively. Significant differences were not found in endotoxin or other factors at sites of gastrointestinal (GI) perforation. These findings suggest that inflammatory cytokines, type II PLA2, and NO are highly involved in the evolution of the pathology of generalized peritonitis.