Epilepsy & behavior : E&B
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Epilepsy & behavior : E&B · Aug 2007
Reliability and validity of a Chinese version of the Quality of Life in Epilepsy Inventory (QOLIE-89).
The aim of the work described here was to develop and validate a Chinese version of the Quality of Life in Epilepsy Inventory-89 (QOLIE-89). ⋯ The psychometric properties of the Chinese version of the QOLIE-89 are good and similar to those of the American version and can be applied to assess quality of life in adult patients with epilepsy in China.
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There is little literature on a possible link between the use of antiepileptic drugs (AEDs) and the occurrence of suicidal ideation. Nevertheless, its occurrence needs to be promptly recognized because it may trigger suicidal attempts. ⋯ All cases occurred in the context of a mood disorder presenting early during LEV therapy. Psychopathological characteristics of suicidal ideation were consistent in all subjects and similar to some features that are described as typical of the so-called interictal dysphoric disorder of epilepsy.
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Epilepsy & behavior : E&B · Aug 2007
Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock.
Using the mouse maximal electroshock-induced seizure model, indicative of tonic-clonic seizures in humans, the present study was aimed at characterizing the interaction between remacemide and valproate, carbamazepine, phenytoin, and phenobarbital. Isobolographic analysis indicated additive interactions between remacemide and valproate, carbamazepine, and phenytoin (for all fixed ratios of tested drugs: 1:3, 1:1, and 3:1). Additivity was also observed between remacemide and phenobarbital applied in proportions of 1:1 and 3:1. ⋯ In contrast, phenobarbital co-administration was associated with decreases in brain remacemide (27%) and desglycinyl-remacemide (9%) concentrations, whereas only remacemide concentrations (increased by 131%) were affected by carbamazepine co-administration. In conclusion, significant and desirable pharmacodynamic interactions were observed between remacemide and valproate, carbamazepine, phenytoin, and phenobarbital. However, the concurrent pharmacokinetic interactions associated with remacemide complicate these observations and do not make remacemide a good candidate for adjunctive treatment of epilepsy.