Epilepsy & behavior : E&B
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Epilepsy & behavior : E&B · Apr 2012
Low serum leptin level is associated with zonisamide-induced weight loss in overweight female epilepsy patients.
Because iatrogenic obesity may hinder medication compliance, it would be a reasonable approach to consider antiepileptic drugs (AEDs) that promote weight loss in overweight patients. We performed an open-label, observational study to assess the effects of zonisamide on weight in overweight female epilepsy patients. In particular, we studied how the basal serum leptin level is related to changes in the weight of these patients. ⋯ The correlation of the serum leptin level with weight loss was still significant after the effect of the initial weight was adjusted (p=0.042). Our study shows that low serum leptin level is associated with weight loss in overweight female epilepsy patients. This result may be beneficial for selecting AEDs and provide clues for the pathophysiology of zonisamide-induced weight loss.
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Epilepsy & behavior : E&B · Apr 2012
Randomized Controlled TrialPregabalin increases slow-wave sleep and may improve attention in patients with partial epilepsy and insomnia.
Insomnia is a common phenomenon particularly in patients with epilepsy. This study was performed to look at the effects of pregabalin, an anticonvulsant known to increase sleep depth and decrease arousals, in patients with insomnia and well-controlled epilepsy. ⋯ Concurrent treatment with pregabalin improves sleep depth in patients with insomnia and epilepsy and improves daytime attention.