Epilepsy & behavior : E&B
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Epilepsy & behavior : E&B · Nov 2013
Multicenter StudyControl of seizures in different stages of partial epilepsy: LACO-EXP, a Spanish retrospective study of lacosamide.
Lacosamide is approved as adjunctive therapy for focal epilepsies. The number of antiepileptic drugs (AEDs) tried is associated with prognosis. This multicenter, retrospective, observational study (LACO-EXP) in Spain in 500 adult patients with focal epilepsies examined the efficacy and tolerability of add-on lacosamide. ⋯ Lacosamide was generally well tolerated. A slower dosage-titration schedule was associated with a lower adverse event rate. Further investigation of the timing of initiation of lacosamide add-on therapy and ideal combinations of AEDs is required.