The journal of nutrition, health & aging
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J Nutr Health Aging · Jan 2000
Review Comparative StudyEnteral and parenteral nutrition in the seriously ill, hospitalized patient: a critical review of the evidence.
Providing nutritional support has become a standard component of managing seriously ill patients. While many studies have documented that providing nutrition support can change nutritional outcomes (amino acid profile, weight gain, nitrogen balance, etc.), there are limited da ta that demonstrate that nutrition support actually influences clinicall y important endpoints. The purpose of this paper is to systematically r eview and critically appraise the literature to examine the relationship between nutritional support and morbidity and mortality in the seriously ill patient. As a product of this critical appraisal of the evidence, clinical recommendations based on rules of evidence are put forward.
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J Nutr Health Aging · Jan 2000
Randomized Controlled Trial Clinical TrialQuality of life and stimulation of weight gain after treatment with megestrol acetate: correlation between cytokine levels and nutritional status, appetite in geriatric patients with wasting syndrome.
The geriatric wasting syndrome (GWS) has been associated with proinflammatory cytokines, depression and progressive decline in quality of life (QOL). The objective of this study was to evaluate the correlation between the changes in cytokine levels and appetite, nutritional markers, and QOL in geriatric patients with GWS following a randomized clinical trial of megestrol acetate (MA) versus placebo. ⋯ In a geriatric nursing home population with weight loss, reduction in cytokine levels after MA treatment correlates with improvement in appetite, prealbumin, albumin, and improvement in quality of life.