The journal of nutrition, health & aging
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J Nutr Health Aging · Jan 2013
Randomized Controlled TrialA randomized controlled Alzheimer's disease prevention trial's evolution into an exposure trial: the PREADViSE Trial.
To summarize the ongoing prevention of Alzheimer's disease (AD) by vitamin E and selenium (PREADViSE) trial as an ancillary study to SELECT (a large prostate cancer prevention trial) and to present the blinded results of the first year as an exposure study. ⋯ Partnering with SELECT led to an AD prevention trial conducted at a very reasonable cost by taking advantage of the experience and efficient clinical trial management found in a cancer cooperative group (Southwest Oncology Group or SWOG). Once unblinded, the RCT and exposure study data have the potential to yield new information on long term exposure to antioxidant supplements under controlled conditions.