Pain medicine : the official journal of the American Academy of Pain Medicine
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Randomized Controlled Trial
Effects of intravenous prostaglandin E1 on pain and body temperature in patients with post-herpetic neuralgia.
Bathing, heating, or sympathetic blockade often alleviates pain due to post-herpetic neuralgia (PHN), suggesting that blood flow may affect PHN pain. Here, we examined the effect of prostaglandin E1 (PGE), which improves blood circulation, on pain and body temperature in patients with PHN. ⋯ Intravenous infusion of PGE produces analgesia associated with elevation of skin temperature in patients with PHN.
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Randomized Controlled Trial
NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomized, double-blind, controlled study with an open-label extension.
To assess the efficacy, tolerability, and safety of NGX-4010, a high-concentration capsaicin dermal patch (capsaicin 640 microg/cm(2), 8%) in patients with postherpetic neuralgia (PHN). ⋯ NGX-4010 is a promising topical treatment for PHN patients, which appears to be tolerable, generally safe, and effective.