Pain medicine : the official journal of the American Academy of Pain Medicine
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Randomized Controlled Trial
Evoked pain analgesia in chronic pelvic pain patients using respiratory-gated auricular vagal afferent nerve stimulation.
Previous vagus nerve stimulation (VNS) studies have demonstrated antinociceptive effects, and recent noninvasive approaches, termed transcutaneous-vagus nerve stimulation (t-VNS), have utilized stimulation of the auricular branch of the vagus nerve in the ear. The dorsal medullary vagal system operates in tune with respiration, and we propose that supplying vagal afferent stimulation gated to the exhalation phase of respiration can optimize t-VNS. ⋯ Chronic pain disorders such as CPP are in great need of effective, nonpharmacological options for treatment. RAVANS produced promising antinociceptive effects for quantitative sensory testing (QST) outcomes reflective of the noted hyperalgesia and central sensitization in this patient population. Future studies should evaluate longer-term application of RAVANS to examine its effects on both QST outcomes and clinical pain.
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This article is aimed at critically evaluating the evidence from systematic reviews (SRs) of spinal manipulation in patients with pain. ⋯ Collectively, these data fail to demonstrate that spinal manipulation is an effective intervention for pain management.
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Randomized Controlled Trial
Randomized, double-blind, placebo-controlled study of the abuse potential of different formulations of oral oxycodone.
The objective of this study was to evaluate the pharmacokinetics and abuse potential of different formulations of oxycodone. ⋯ Intact, orally administered oxycodone CR produced less drug liking and high than IR oxycodone, and required approximately twofold greater doses to produce subjective effects comparable to IR oxycodone.
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The objective of this study was to quantify the network complexity, information flow, and effect of critical-node failures on a prototypical regional anesthesia and perioperative pain medicine (RAPPM) service using social network analysis. ⋯ The RAPPM service entails considerable network complexity and increased hierarchy, but low centrality. The network is at considerable fragmentation risk from even single-node failure.