Pain medicine : the official journal of the American Academy of Pain Medicine
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Multicenter Study Observational Study
Longitudinal observation of treatment patterns and outcomes for patients with fibromyalgia: 12-month findings from the reflections study.
To describe 12-month treatment patterns and outcomes for patients starting a new medication for fibromyalgia in routine clinical practice. ⋯ In this real-world setting, patients with fibromyalgia reported modest improvements, high resource, and medication use, and were satisfied with the care they received. Cohort differences were difficult to discern because of the high rates of drug discontinuation and concomitant medication use over the 12-month study period.
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Review Meta Analysis
Are older adults with chronic musculoskeletal pain less active than older adults without pain? A systematic review and meta-analysis.
To compare the overall levels of physical activity of older adults with chronic musculoskeletal pain and asymptomatic controls. ⋯ Older adults with chronic pain appear to be less active than asymptomatic controls. Although this difference was small, it is likely to be clinically meaningful. It is imperative that clinicians encourage older people with chronic pain to remain active as physical activity is a central non-pharmacological strategy in the management of chronic pain and is integral for healthy aging. Future research should prioritize the use of objective measurement of physical activity.
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Randomized Controlled Trial
Intravenous magnesium for chronic complex regional pain syndrome type 1 (CRPS-1).
To assess the effects of intravenous administration of magnesium on complex regional pain syndrome type 1 (CRPS-1), a randomized double-blind placebo-controlled trial was performed. ⋯ Administration of the physiological competitive N-methyl-D-aspartate receptor antagonist magnesium in chronic CRPS provides insufficient benefit over placebo. Future research should focus on patients with acute CRPS and early signs and symptoms of central sensitization.
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To investigate the possible mechanisms of topical analgesics in relieving pain in an animal model of muscular inflammation. ⋯ This study suggests that topical analgesics may reduce the nociceptive input from inflamed muscles via a reflex mechanism by activating the cutaneous nociceptive afferents.