Acta medica Scandinavica. Supplementum
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Acta Med. Scand. Suppl. · Jan 1982
Review Clinical Trial Controlled Clinical TrialRebound phenomena following withdrawal of long-term beta-adrenoceptor blockade.
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Acta Med. Scand. Suppl. · Jan 1982
Randomized Controlled Trial Clinical TrialSelf-control of interbeat interval and pulse transit time at rest and during exercise. A preliminary report.
Attempts were made to establish self-control of interbeat interval (IBI) and pulse transit time (PTT) by providing appropriate biofeedback information to volunteers at rest and during dynamic and isometric exercise. Product feedback (IBI X PTT) was found more reliable than simple heart rate (HR) and systolic blood pressure (SBP) during dynamic exercise. ⋯ Possible reasons for this failure are discussed. Preliminary results of feedback training given to 7 anginal patients suggest that such procedures might help to lower nitroglycerin consumption, decrease the frequency of anginal attacks and increase exercise tolerance.
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Acta Med. Scand. Suppl. · Jan 1982
Haemodynamic effects of prenalterol in patients with severe congestive heart failure--NYHA III-IV.
In 12 patients with severe congestive heart failure due to ischaemic heart disease (n = 6) and due to congestive cardiomyopathy (n = 6) the haemodynamic effects of a new beta 1-agonist, prenalterol, were studied. Left ventricular (LV) function was studied before and 20 min after infusion of 12 mg prenalterol. Heart rate was kept constant by atrial pacing at a rate of 100 min-1 unless intrinsic heart rate exceeded it. ⋯ Our study could demonstrate, even in patients with severe heart failure, a sustained positive inotropic effect of prenalterol leading to an improved left ventricular contractility, relaxation and compliance. LV power and work was enhanced. The increase of oxygen demand seemed to be counterbalanced by an improved perfusion of particularly subendocardial layers indicated by an increased transmyocardial pressure gradient.