The Journal of critical illness
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In patients with shock and evidence of hypoperfusion, target therapy at increasing oxygen delivery and decreasing oxygen consumption. To augment delivery, increase arterial oxygenation (with mechanical ventilation and high levels of inspired oxygen), hemoglobin level to at least 10 g/dL (with transfusions of red blood cells), and cardiac output (with hydration and inotropic support). ⋯ To reduce oxygen consumption, consider antipyretics (to lower metabolic demand) and mechanical ventilation plus sedatives or paralytics (to decrease the work of breathing). Continue therapy until oxygen consumption is no longer coupled to delivery.
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Elderly patients are susceptible to acute renal failure largely because of functional impairment of the kidneys secondary to diseases such as arteriosclerosis, hypertension, and heart failure. Successful prevention of renal failure in the elderly hinges on understanding the age-associated changes in renal anatomy and physiology. To prevent renal failure, rehydrate elderly patients who suffer significant fluid loss to avoid volume depletion. In addition, maintain adequate blood pressure in these patients, consider glomerular filtration rate when determining the dosage of nephrotoxic antibiotics, and administer saline preparation before injecting radiocontrast dyes.