São Paulo medical journal = Revista paulista de medicina
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Fungi are ubiquitous in the environment. They are able to grow in water and many of them may be opportunistic pathogens. ⋯ Both RWs and NRWs are potential reservoirs for many types of fungi. Many of these may become opportunistic pathogens if they infect immunosuppressed individuals. Furthermore, this study confirms that fungi are able to grow even when chlorine and pH parameters are within the standards recommended.
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Findings regarding the effects of hyperuricemia on renal function and mortality have been inconsistent. ⋯ In patients with CKD in stages 3-5, hyperuricemia was associated with higher risk of incident renal replacement therapy and all-cause mortality. Whether treatment with uric acid-lowering drugs in these patients would improve their outcomes merits further investigation.
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Observational Study
Tocilizumab for juvenile idiopathic arthritis: a single-center case series.
Juvenile idiopathic arthritis (JIA) is the commonest chronic rheumatic disease among children. When not treated effectively, JIA can lead to functional disability, due to joint damage, along with long-term morbidities. ⋯ Tocilizumab therapy should be considered for treating patients with diagnoses of pJIA or sJIA who are resistant to non-biological DMARDs and/or other biological therapies.
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Exposure to air pollutants has several effects on human health, including during pregnancy. ⋯ It was possible to identify that maternal exposure to benzene and toluene has an acute effect on preterm delivery.
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Lung cancer is the fourth most common cancer in Brazil. In the 2000s, better understanding of molecular pathways led to development of epidermal growth factor receptor (EGFR)-targeted treatments that have improved outcomes. However, these treatments are unavailable in most Brazilian public healthcare services (Sistema Único de Saúde, SUS). ⋯ Reducing drug acquisition costs may improve access to EGFR-targeted therapy for lung cancer.