São Paulo medical journal = Revista paulista de medicina
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Findings regarding the effects of hyperuricemia on renal function and mortality have been inconsistent. ⋯ In patients with CKD in stages 3-5, hyperuricemia was associated with higher risk of incident renal replacement therapy and all-cause mortality. Whether treatment with uric acid-lowering drugs in these patients would improve their outcomes merits further investigation.
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Nonadherence to antiretroviral therapy (ART) may lead to viral replication and development of antiretroviral resistance. ⋯ Encouragement of adherence to antiretroviral therapy is one of the fundamental pillars of treatment for HIV-infected patients. The high proportion of nonadherence (28.4%) and the predictive factors related to this indicate that it is necessary to improve patients' adherence to antiretroviral therapy.
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Observational Study
Tocilizumab for juvenile idiopathic arthritis: a single-center case series.
Juvenile idiopathic arthritis (JIA) is the commonest chronic rheumatic disease among children. When not treated effectively, JIA can lead to functional disability, due to joint damage, along with long-term morbidities. ⋯ Tocilizumab therapy should be considered for treating patients with diagnoses of pJIA or sJIA who are resistant to non-biological DMARDs and/or other biological therapies.
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Lung cancer is the fourth most common cancer in Brazil. In the 2000s, better understanding of molecular pathways led to development of epidermal growth factor receptor (EGFR)-targeted treatments that have improved outcomes. However, these treatments are unavailable in most Brazilian public healthcare services (Sistema Único de Saúde, SUS). ⋯ Reducing drug acquisition costs may improve access to EGFR-targeted therapy for lung cancer.