São Paulo medical journal = Revista paulista de medicina
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Hepatotoxicity is a potential complication from the usage of various illicit drugs, possibly consequent to their liver metabolism, but information on this is scarce in the medical literature. ⋯ Chronic marijuana usage, on its own or in association with other drugs, was associated with hepatic morphologic and enzymatic alterations. This indicates that cannabinoids are possible hepatotoxic substances.
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Patients with metastatic non-small cell lung cancer are deemed incurable, but they may derive some benefit from systemic palliative chemotherapy. Recently, with the introduction of epidermal growth factor receptor (EGFR) antagonists such as gefitinib (Iressa), an effective and less toxic option is now available for the treatment of such patients. ⋯ We concluded that gefitinib is an important addition to the therapeutic armamentarium for patients with metastatic non-small cell lung cancer.
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Cigarette smoke, whether inhaled voluntarily or not, causes damage to the mother-infant pair. The antenatal period may present the best opportunity for performing effective anti-smoking campaigns. ⋯ Cigarette smoke, whether inhaled voluntarily or not, has an unfavorable effect on the mother-infant pair.
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Prostate cancer is the most frequent solid genitourinary neoplasm in men. Involvement of several genes has been described in the promotion and progression of prostate carcinoma. ⋯ One-third of prostate adenocarcinomas express p53 protein, and this characteristic is related to tumor stage. HER2/neu is frequently expressed in prostate carcinomas, with no correlation with histological parameters. BCL2 is rarely expressed, and together with proliferative activity has no relationship with prognostic pathological variables in these neoplasms.
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Case Reports
Central retinal vein prethrombosis as an initial manifestation of protein S deficiency.
Retinal vein thrombosis is most common in old people, and is often associated with systemic vascular disease. One of its rare systemic causes is protein S deficiency. ⋯ A case of a 21-year-old woman with retinal vein prethrombosis associated only with protein S deficiency is described. She presented with acutely reduced visual acuity and a central scotoma in her left eye. Warfarin therapy was initiated, and complete improvement in ophthalmoscopic findings was subsequently observed. This case illustrates that protein S deficiency is a factor that should be considered in cases of retinal vein occlusion, particularly in young patients.