São Paulo medical journal = Revista paulista de medicina
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Observational Study
Tocilizumab for juvenile idiopathic arthritis: a single-center case series.
Juvenile idiopathic arthritis (JIA) is the commonest chronic rheumatic disease among children. When not treated effectively, JIA can lead to functional disability, due to joint damage, along with long-term morbidities. ⋯ Tocilizumab therapy should be considered for treating patients with diagnoses of pJIA or sJIA who are resistant to non-biological DMARDs and/or other biological therapies.
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Exposure to air pollutants has several effects on human health, including during pregnancy. ⋯ It was possible to identify that maternal exposure to benzene and toluene has an acute effect on preterm delivery.
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Lung cancer is the fourth most common cancer in Brazil. In the 2000s, better understanding of molecular pathways led to development of epidermal growth factor receptor (EGFR)-targeted treatments that have improved outcomes. However, these treatments are unavailable in most Brazilian public healthcare services (Sistema Único de Saúde, SUS). ⋯ Reducing drug acquisition costs may improve access to EGFR-targeted therapy for lung cancer.