Expert opinion on pharmacotherapy
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Expert Opin Pharmacother · Apr 2003
ReviewAssessment and management of acute pain in high-risk neonates.
Neonates in the neonatal intensive care unit experience hundreds of painful procedures at a time of rapid neurological development. Although the immediate responses to pain may be protective, the potential long-term effects of early and under-treated pain are concerning. As pain assessment is the first step in the provision of appropriate and timely pain management, attention should be directed to the quantification of pain in terms of its location, severity, intensity and duration. ⋯ In order to effectively implement pain measures in the clinical setting, the psychometric properties of reliability, validity, feasibility and clinical utility must be established. This review paper will highlight the importance of neonatal pain assessment and examine the psychometric properties of various measures of neonatal pain. Pharmacological and non-pharmacological interventions to manage acute pain in high-risk neonates will be addressed and future research topics will be proposed.
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Postoperative nausea and vomiting (PONV) are two of the most common and unpleasant side effects following anaesthesia and surgery. Despite the development of new anti-emetics and a vast amount of published research, PONV continues to be a problem, especially in high-risk patients. ⋯ This article will discuss the risk factors and physiology of PONV, currently available therapies, the use of a multimodal approach and the cost-effectiveness of PONV management. Finally, recommendations for the prophylaxis and treatment of PONV will be discussed.