Expert opinion on pharmacotherapy
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Expert Opin Pharmacother · Oct 2017
ReviewThrombopoietin-receptor agonists for children with immune thrombocytopenia: a systematic review.
We conducted a systematic review to assess the efficacy and safety of Thrombopoietin-receptor agonists (TPOras) for pediatric immune thrombocytopenia (ITP). ⋯ TPOras might improve both durable and overall platelet response in pediatric ITP, compared with placebo.
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Expert Opin Pharmacother · Oct 2017
ReviewAn update on new antibiotic prophylaxis and treatment for urinary tract infections in children.
This review focuses on the treatment of urinary tract infections (UTI) in children and in particular its recent changes. Areas covered: Acute pyelonephritis, acute cystitis and asymptomatic bacteriuria or asymptomatic infections have to be clearly distinguished. Prompt treatment is required in pyelonephritis and cystitis, but not in asymptomatic bacteriuria or infection, in order to avoid selection of more virulent strains. ⋯ Therefore overconsumption in low-risk settings should be absolutely avoided. The prevalence of infections with E. coli producing extended spectrum ß-lactamase (ESBL) is increasing and pediatricians should be aware about the specific treatment options. Any recommendation about (initial) antibiotic treatment should be regularly updated and adapted to local resistance profiles and to economic factors in different health systems.