Clinical toxicology
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Acute nicotine poisoning by enema is an uncommon event. A review of the last 70 years of the English and Spanish medical literature has failed to reveal a case of nicotine poisoning by enema in an adult. ⋯ We have recently treated an adult for acute nicotine poisoning from a tobacco enema. This unusual case allowed us to observe some of the complex pharmacologic responses of the body to nicotine.