Clinical toxicology
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Acute nicotine poisoning by enema is an uncommon event. A review of the last 70 years of the English and Spanish medical literature has failed to reveal a case of nicotine poisoning by enema in an adult. ⋯ We have recently treated an adult for acute nicotine poisoning from a tobacco enema. This unusual case allowed us to observe some of the complex pharmacologic responses of the body to nicotine.
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Clinical toxicology · Jan 1976
Tricyclic antidepressant overdosage: experimental studies on the management of circulatory complications.
Tricyclic antidepressant overdosage may be complicated by cardiac arrhythmias, which were sometimes difficult to treat prior to the use of sodium bicarbonate. Experiments have been done with several antiarrhythmics in an attempt to define the optimum treatment. ⋯ Practolol, although reversing the arrhythmias, tends to cause hypotension. Other drugs tried were less effective.