Clinical breast cancer
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Clinical breast cancer · Jun 2012
Randomized Controlled Trial Multicenter StudyEffect of different doses of metformin on serum testosterone and insulin in non-diabetic women with breast cancer: a randomized study.
This is a randomized controlled trial to test the effect of different doses of metformin in patients with breast cancer and without diabetes, with the aim of modifying the hormonal and metabolic parameters linked to breast cancer prognosis. Analysis of the results suggest that the dose of 1500 mg/d of metformin causes a significant reduction of insulin and testosterone serum levels. ⋯ Both these changes might have a prognostic importance.