Sleep medicine
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Randomized Controlled Trial
Evaluation of autoCPAP devices in home treatment of sleep apnea/hypopnea syndrome.
Quality of life (QOL) and sleepiness for patients with sleep apnea/hypopnea syndrome (SAHS) might improve with continuous positive airway pressure devices working in auto-adjust mode (autoCPAP) by allowing pressure modulations following patient needs. Clinical comparisons between devices driven by different algorithms are needed. ⋯ AutoCPAP is equally as effective as fixed CPAP for long-term home treatment in severe SAHS patients.
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Multicenter Study Clinical Trial
A 52-week open-label study of the long-term safety of ropinirole in patients with restless legs syndrome.
To assess the long-term safety and efficacy of ropinirole in the treatment of patients with restless legs syndrome (RLS) over 52 weeks. ⋯ Ropinirole was well tolerated and therapeutic efficacy was maintained over 52 weeks in patients with RLS.
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Increasing evidence suggests a significant comorbidity between attention-deficit/hyperactivity disorder (ADHD) and restless legs syndrome (RLS). Iron deficiency may underlie common pathophysiological mechanisms in subjects with ADHD plus RLS (ADHD+RLS). To date, the impact of iron deficiency, RLS and familial history of RLS on ADHD severity has been scarcely examined in children. These issues are addressed in the present study. ⋯ Children with ADHD and a positive family history of RLS appear to represent a subgroup particularly at risk for severe ADHD symptoms. Iron deficiency may contribute to the severity of symptoms. We suggest that clinicians consider assessing children with ADHD for RLS, a family history of RLS, and iron deficiency.