Sleep medicine
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Randomized Controlled Trial
Beneficial effect of donepezil on obstructive sleep apnea: a double-blind, placebo-controlled clinical trial.
Previous publications have shown beneficial effects of cholinergic medication on obstructive sleep apnea (OSA) in Alzheimer's disease (AD) patients. We hypothesized that cholinergic medication could also improve OSA in non-AD patients. The present study evaluated the effects of donepezil on OSA in non-AD patients. ⋯ Donepezil treatment improved obstructive sleep apnea index, oxygen saturation, and sleepiness in parallel with a reduction in sleep efficiency. Our findings support the concept that cholinergic transmission may influence breathing regulation in OSA patients.
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To examine the quantity and quality of insomnia symptoms as predictors of treatment for depression in the largest cohort study to date. ⋯ These data suggest an association between insomnia symptoms and moderately increased risk of clinically significant depression outcomes. Insomnia should be considered as a component in prediction models for new-onset depression.
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Letter Case Reports
Post H1N1 vaccination narcolepsy-cataplexy with decreased CSF beta-amyloid.