Sleep medicine
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To investigate the effect of intravenous (IV) iron (500 mg ferric carboxymaltose [FCM] as a single dose) on restless legs syndrome (RLS) severity on a day-to-day basis. ⋯ FCM led to a considerable improvement in RLS in the responder group within about one week. These findings are clinically relevant, especially for patients with severe RLS symptoms and iron deficiency, since a change or uptitration of RLS-specific medication can be avoided or postponed in these patients due to the rapid response to IV FCM treatment.
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To evaluate the efficacy and side effect profile of sodium oxybate in the treatment for narcolepsy-cataplexy in the pediatric age group. ⋯ Sodium oxybate is effective in alleviating sleepiness and cataplexy in childhood onset narcolepsy-cataplexy. The therapeutic response was sustained over time, and without development of tolerance. Forty percent of the subjects experienced adverse effects.
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Randomized Controlled Trial
Efficacy of vitamins C, E, and their combination for treatment of restless legs syndrome in hemodialysis patients: a randomized, double-blind, placebo-controlled trial.
Restless legs syndrome (RLS) is a common disorder in hemodialysis patients that leads to insomnia and impaired quality of life. Because high oxidative stress has been implicated in the pathogenesis of RLS, we sought to evaluate the efficacy of vitamins C and E and their combination in reducing the severity of RLS symptoms in hemodialysis patients in this randomized, double-blind, placebo-controlled, four-arm parallel trial. ⋯ Vitamins C and E and their combination are safe and effective treatments for reducing the severity of RLS in hemodialysis patients over the short-term.
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Restless legs syndrome (RLS) is characterised by an urge to move in response to unusual sensations in the legs. Patients experience difficulty describing their RLS sensations, resulting in a diverse range of descriptors which have not been fully categorised. The purpose of this study was to describe RLS sensations and to evaluate the accuracy of current diagnostic descriptors. ⋯ The most frequently cited descriptors in this study differ from the terminology used in the RLS diagnostic criteria. Inclusion of these frequently used descriptors may improve the diagnostic accuracy of RLS. Our data emphasise the need for an international, large scale, multicultural study to determine the most accurate diagnostic descriptors to define RLS more clearly.