Paediatric respiratory reviews
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Paediatr Respir Rev · Jun 2009
ReviewRole of ventilation in RSV disease: CPAP, ventilation, HFO, ECMO.
Respiratory syncytial virus (RSV) lower respiratory tract disease may present as bronchiolitis, an obstructive lung disease with hyperinflation, or pneumonitis, a restrictive parenchymal disease with diffuse consolidation, a large intrapulmonary shunt and acute respiratory distress syndrome (ARDS). Although a significant proportion of those admitted to hospital will require some form of respiratory support, there have been few randomised studies to determine which is the most beneficial. ⋯ Current practice regarding ventilator support is largely based on clinical judgment and case reports. Multicentre randomised trials with long-term follow-ups are urgently required.
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Paediatr Respir Rev · Jun 2009
Sublingual immunotherapy for children: Are we there yet? Defining its role in clinical practice.
Immunotherapy in various forms has been used to treat allergic disorders since the early 19th century. Subcutaneous immunotherapy is now well established for the treatment of insect anaphylaxis and allergic rhinitis. ⋯ Several trials have also shown a potential immunomodulatory effect of sublingual immunotherapy, with evidence of a reduction in the progression from allergic rhinitis to asthma and reduced new aeroallergen sensitisation. This review will give an overview of the current evidence for sublingual immunotherapy in the paediatric population.