Clinical calcium
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Minodronic acid hydrate is one of the new-generation bisphosphonates containing nitrogen. This drug has an inhibitory effect on bone resorption by suppressing the osteoclastic function, and it is being developed as a therapeutic drug of osteoporosis. In non-clinical study, the drug has an inhibitory effect on the decrease of the bone mineral density and the bone intensity in ovariectomized rat osteoporosis models. ⋯ The other study conducted that minodronic acid hydrate increases the bone mineral density at least equivalent to that of alendronate for 48 weeks. The safety analysis in the latest study revealed that the adverse events of minodoronic acid hydrate have no statistically significant differences from the placebo group. We expect that minodronic acid hydrate will be used for a number of patients with osteoporosis as a potent and safe domestically created bisphosphonate in the near future.