HPB : the official journal of the International Hepato Pancreato Biliary Association
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Randomized Controlled Trial
Ketamine does not inhibit interleukin-6 synthesis in hepatic resections requiring a temporary porto-arterial occlusion (Pringle manoeuvre): a controlled, prospective, randomized, double-blinded study.
Previous studies have shown that interleukin-6 (IL-6) levels correlated with mortality in critically ill patients. ⋯ Ketamine does not seem to have an effect on plasma levels of IL-6. This could be interpreted as a potential finding associated with outcome as we did not encounter any deaths or major complications. Further studies will likely be needed to determine the range of IL-6 levels associated with survival and mortality, and whether it could be a predictor of survival.