HPB : the official journal of the International Hepato Pancreato Biliary Association
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Multicenter Study
Predictors of surgical site infection after liver resection: a multicentre analysis using National Surgical Quality Improvement Program data.
Postoperative infections are frequent complications after liver resection and have significant impact on length of stay, morbidity and mortality. Surgical site infection (SSI) is the most common nosocomial infection in surgical patients, accounting for 38% of all such infections. ⋯ These findings may contribute towards the identification of patients at risk for SSI and the development of strategies to reduce the incidence of SSI and subsequent costs after liver resection.
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Surgical resection remains the only potentially curative treatment for colorectal liver metastases (CLM). However, involvement of both the hepatic lobes or extrahepatic disease (EHD) can be a contra-indication for resection. The aim of the present study was to examine the addition of combined positron emission and computed tomography (PET/CT) to CLM staging to assess the effects upon staging and management. ⋯ The addition of PET/CT led to management changes in over one-third of patients but there was no correlation between alterations in staging or management and the Fong clinical risk score; suggesting that PET/CT should be utilized, where available, in the pre-operative staging of CLM patients.
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Comparative Study
Safety and efficacy of preoperative right portal vein embolization in patients at risk for postoperative liver failure following major right hepatectomy.
Right portal vein embolization (RPVE) has been utilized with or without segment IV (RPVE + IV) prior to hepatectomy to induce hypertrophy and prevent liver insufficiency in patients with a predicted future liver remnant (FLR) of ≤30% or cirrhosis. ⋯ Right portal vein embolization (±segment IV) is a safe and effective modality to increase FLR volume. Post-embolization complications and short-term outcomes after resection are acceptable and are similar in both RPVE and RPVE + IV.
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Comparative Study
Route of gastroenteric reconstruction in pancreatoduodenectomy and delayed gastric emptying.
Delayed gastric emptying (DGE) is a frequent complication after pancreatoduodenectomy. Some previous studies suggest that antecolic (compared with retrocolic) gastroenteric reconstruction lowers the incidence of DGE. The present study was performed to investigate the relation between the route of gastroenteric reconstruction and DGE after pancreatoduodenectomy. ⋯ The incidence of DGE did not differ between the study groups. 'Primary' DGE was more frequent in the retrocolic group, but in multivariable analysis, no association between the route of reconstruction and primary DGE was found. The preferred route for gastroenteric reconstruction after pancreatoduodenectomy remains to be investigated in a well-powered, randomized, controlled trial.
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Traditional survival estimates after resection for pancreatic cancer are based on clinicopathological variables at the time of diagnosis. Estimates have not reflected time survived after resection, as investigated for other malignancies. The aim of the present study was to understand how survival estimates change after pancreatic resection for cancer based on time already survived (conditional survival). ⋯ The available prognostic system for PDAC underestimated survival compared with actual survival in the present study. Conditional survival estimates, based on accrued lifespan, were better than either predicted or actual survival, suggesting that survival is a dynamic, rather than static, concept. Conditional survival may, therefore, be a useful tool to allow patients and clinicians to project subsequent survival based on time accrued since resection.