Patologicheskaia fiziologiia i èksperimental'naia terapiia
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Patol Fiziol Eksp Ter · Oct 2015
[The role of erythrocyte microvesiculation and hemoglobin glycation in hemorheological disordes during burn injury].
Hemorheological disorders play an important part in pathogenesis of acute period of burn injury. This mechanism remains practically unstudied. Thus, unknown is the role of hemoglobin glycation and erythrocyte microvesiculation in the decrease in erythrocyte deformability after thermal trauma. ⋯ It was found that the amount of HbA₁c in red blood cells of burn patients demonstrated a 2-fold increase compared to healthy donors. In the experiments in vitro it was proved that deformability of erythrocytes correlates with the level of hemoglobin glycation. Hb glycation leads to the increased rigidity of erythrocytes also by increasing their microvesiculation. The number of microvesicles derived from red blood cells of burn patients demonstrated a 3.47-fold increase compared to healthy donors. An important reason for microvesiculation is the destabilization of lipid complex of erythrocyte membrane, which is accompanied by the increase in the erythrocyte negative charge. It can be concluded that Hb glycation and redistribution of erythrocyte membrane phospholipids are he important reasons for the increase erythrocyte microvesiculation and are accompanied by the decrease in erythrocyte deformability after thermal trauma.
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Patol Fiziol Eksp Ter · Jul 2015
[The influence of erythrocyte-derived microvesicles on aggregation of platelets in burn injury].
Burn Injury is accompanied by a significant homeostasis disorder, including the disorder of primary homeostasis, associated with aggregation of platelets. The role of erythrocyte-derived microvesicles in this process has not undergone thorough research. Microvesicles were isolated from washed erythrocytes after one day of storage by ultracentrifugation at 100000 g. ⋯ The main reason is a considerably lower antithrombin activity in the erythrocyte microvesicles of bum patients. Thus, we can conclude that the decrease of antiaggregation and antithrombin activity of erythrocyte microvesicles associated with the increase in their concentration in blood contributes to thrombophilia of bum patients. Keywords: erythrocytes, microvesicles, bum injury, platelet aggregation, antithrombin activity
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Patol Fiziol Eksp Ter · Apr 2015
Comparative Study[Atrial fibrillation and condition of vegetative nervous system: features of tactics and medical aid rendering at the pre-hospital stage].
Comparative retrospective study of emergency action results for 1051 patients with atrial fibrillation attacks and their management tactics assessment at a pre-hospital stage was done. It was found that occurrence of an attack of atrial fibrillation at a pre-hospital stage is accompanied expressed vegetative imbalance. Antiarrhythmic therapy using diazepam for atrial fibrillation promotes fast decrease of sympathicotonia at a pre-hospital stage and improves treatment efficacy in the first hour of observation of patients.
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Patol Fiziol Eksp Ter · Oct 2014
Review[The importance of the cortex and subcortical structures of the brain in the perception of acute and chronic pain].
This review presents the current data in the literature about the importance of the cortex and subcortical structures of the brain in the perception of acute and chronic pain. Discussed the importance of various areas of the brain in perception discriminative and affective components of pain. Discusses also gender differences in pain perception depending on the functional activity of brain cortex and antinociceptive subcortical structures. ⋯ It is proved that the decrease in the volume of gray and white matter of cerebral cortex and subcortical structures is a consequence and not the cause of chronic pain syndrome. Discusses the features activate and deactivate certain areas of the cortex of the brain in acute and chronic pain. Analyzed same features the activation of several brain structures in migraine and cluster headache.
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Patol Fiziol Eksp Ter · Jan 2013
[The response of cerebral blood flow and systemic arterial blood pressure to hypercapnia and hypocapnia in humans].
In 11 healthy volunteers 21 +/- 3.7 years old was monitored cerebral blood flow (CBF) by transcranial Doppler (TCD) of middle cerebral artery and mean hemodynamic arterial blood pressure (MAP) by continuous non-invasive measurement "beat-to-beat" at normocapnia, hypercapnia and hypocapnia. Hypercapnia was creating by rebreathing, hypocapnia was creating by spontaneous hyperventilation. ⋯ During hypocapnia velocity CBF and PetCO2 were significantly decreased at 10 s, and MAP was not changed. We have installed the threshold PetCO2 42 (41; 44) mm Hg, below which amplification CBF occurs at a constant MAP and reflects the true cerebrovascular reactivity to CO2.