Patologicheskaia fiziologiia i èksperimental'naia terapiia
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Patol Fiziol Eksp Ter · Oct 2011
Review[Role of heat shock proteins in the mechanism of cardioprotective effect of transient hyperthermia and delayed preconditioning].
This review article focuses on discussing the role of the heat shock proteins (HSP) in myocardial protection against ischemia-reperfusion injury. In the present time, it has also been recognized that HSP may responsible for the increase in cardiac tolerance to ischemia-reperfusion after heat shock or after delayed ischemic preconditioning. The enhancement of the HSP expression in transgenic mice promotes an elevation of cardiac resistance to ischemia-reperfusion. ⋯ It has been established that deletion of the HSP70.1 and HSP70.3 genes abolishes a cardioprotective effect of delayed preconditioning. The mechanism by which HSP protect the heart against ischemia-reperfusion remains obscure. It has been proposed that HSP protect the heart via refolding proteins, an increase in 5'-nucleotidase activity, an improvement of Ca(2+)-pump function in sarcoplasmic reticulum during ischemia-reperfusion.
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It is shown that restoration of plasma volume in 3-day-old pigs 6-12 hours after a 33% blood loss is a part of fluid elimination from the body as it occurs due to transfer of interstitial and, probably, intracellular liquid into the circulation and is accompanied by activation of diuresis. Activation of this process is not participated neither by hydrocortisone nor ACTH. Vasopressin and aldosterone have a negative effect on intravasation of interstitial fluid.
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Patol Fiziol Eksp Ter · Oct 1999
Historical Article[The beginnings and development of pathophysiology at the Imperial Moscow University--the 1st Moscow Medical Institute--the I. M. Sechenov Moscow Medical Academy (on the 150th anniversary of the Department of Pathophysiology of the I. M. Sechenov Moscow Medical Academy)].
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Patol Fiziol Eksp Ter · Jul 1992
ReviewDiffuse noxious inhibitory controls (DNIC) in animals and in man.
Some neurones in the dorsal horn of the spinal cord are strongly inhibited when a nociceptive stimulus is applied to any part of the body, distinct from their excitatory receptive fields. This phenomenon was termed "Diffuse Noxious Inhibitory Controls" (DNIC). DNIC influence only convergent neurones: the other cell types which are found in the dorsal horn, including specific nociceptive neurones, are not affected by this type of control. ⋯ In man, exactly analogous results have been obtained by means of combined psychophysical measurements and recordings of nociceptive reflexes. Electrical stimulation of the sural nerve at the ankle simultaneously induces a nociceptive reflex in a flexor muscle of the knee (the RIII reflex) and a painful sensation from the territory of the nerve. Painful heterotopic conditioning stimuli, no matter whether thermal, mechanical or chemical in nature, depress both the reflex and the associated painful sensation, with stronger effects being observed with more intense conditioning stimuli.(ABSTRACT TRUNCATED AT 400 WORDS)