American journal of physiology. Endocrinology and metabolism
The most recent articles from:
January 2004
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Am. J. Physiol. Endocrinol. Metab. · Jan 2004
Comparative StudyDistributed control of glucose uptake by working muscles of conscious mice: roles of transport and phosphorylation.
Muscle glucose uptake (MGU) is determined by glucose delivery, transport, and phosphorylation. C57Bl/6J mice overexpressing GLUT4, hexokinase II (HK II), or both were used to determine the barriers to MGU. A carotid artery and jugular vein were catheterized for arterial blood sampling and venous infusions. ⋯ In conclusion, control of MGU shifts from membrane transport at rest to phosphorylation during exercise. Glucose transport is not normally a significant barrier during exercise. However, when the phosphorylation barrier is lowered by HK II overexpression, glucose transport becomes a key site of control for regulating MGU during exercise.