Autonomic neuroscience : basic & clinical
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Review
Central autonomic integration of psychological stressors: focus on cardiovascular modulation.
During stress the sympathoadrenal system and the hypothalamo-pituitary-adrenal axis act in a coordinated manner to force changes within an animal's current physiological and behavioral state. Such changes have been described as 'fight flight' or stress responses. The central nervous system may generate a stress response by different neural circuits, this being dependent upon the type of stressor presented. ⋯ In contrast, with exposure to psychological stress the means by which autonomic outflow is regulated has not been fully established. This review discusses recent observations of autonomic flow, cardiovascular components in particular, during psychological stress and the possible implications these may have for our understanding of the central nervous system. In addition, an update of recent findings concerning several regions thought to be important to the regulation of autonomic function during psychological stress exposure is provided.
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Cardiopulmonary receptors relay signals to the central nervous system via vagal and spinal visceral afferents. To date there are no detailed topographical studies in mice indicating the distribution of central neurones activated following stimulation of cardiopulmonary afferents. In anaesthetised mice, we injected the 5-HT(3) receptor agonist phenylbiguanide (PBG), a drug that is known to stimulate cardiopulmonary afferent C-fibres, into the right atrium of the heart and mapped c-Fos expression within specific regions of the central nervous system. ⋯ PBG injections had no significant effects on the number of c-Fos-positive catecholaminergic neurones within the C1/A1, C2/A2, A5, A6 and A7 cell groups. Likewise, PBG injections had no significant effects on c-Fos expression in other central regions involved in cardiorespiratory control or cardiorespiratory reflexes (selected non-catecholaminergic nuclei in the medulla and midbrain periaqueductal gray, the paraventricular nucleus of the hypothalamus and the central nucleus of the amygdala). Identification of specific regions of the nTS complex involved in relaying signals from afferent cardiopulmonary C-fibres to the central nervous system will be useful for future studies aimed at understanding neural mechanisms underlying cardiopulmonary reflexes and physiological responses to cardiopulmonary disease.