Developmental medicine and child neurology
-
Dev Med Child Neurol · Aug 1995
Comparative Study Clinical Trial Controlled Clinical TrialLorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus.
Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial. Convulsions were controlled in 76 per cent of patients treated with a single dose of lorazepam and 51 per cent of patients treated with a single dose of diazepam. ⋯ No patient who received lorazepam required admission to the intensive care unit for either respiratory depression or persisting status epilepticus. Rectally administered lorazepam appeared to be particularly valuable (100 per cent efficacy) when venous access was not possible.