Developmental medicine and child neurology
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Dev Med Child Neurol · Nov 2014
Comparative Study Observational StudyFunctional status at 18 months of age as a predictor of childhood disability after neonatal hypoxic-ischemic encephalopathy.
In children with neonatal hypoxic-ischemic encephalopathy (HIE), we examined the association between 18-month functional status by parental report and disability at 6-7 years. ⋯ Poor independent functioning by parental report at 18 months in children with HIE was associated with childhood disability.
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Dev Med Child Neurol · Nov 2014
Comparative StudyDiffusion tensor imaging of the brainstem in children with achondroplasia.
The aims of this study were to compare, using diffusion tensor imaging (DTI) of the brainstem, microstructural integrity of the white matter in children with achondroplasia and age-matched participants and to correlate the severity of craniocervical junction (CCJ) narrowing and neurological findings with DTI scalars in children with achondroplasia. This study also aimed to assess the potential role of fibroblast growth factor receptor type 3 on white matter microstructure. ⋯ The reduction in fractional anisotropy and increase in diffusivities in the lower brainstem of participants with achondroplasia may reflect secondary encephalomalacic degeneration and cavitation of the affected white matter tracts as shown by histology. In children with achondroplasia, DTI may serve as a potential biomarker for brainstem white matter injury and aid in the care and management of these patients.