Developmental medicine and child neurology
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Dev Med Child Neurol · May 2015
Randomized Controlled TrialMotor endplate-targeted botulinum toxin injections of the gracilis muscle in children with cerebral palsy.
Intramuscular botulinum toxin-A (BoNT-A) injections reduce spasticity by blocking neurotransmission at the motor endplate (MEP). The goal of this study was to assess the reduction in spasticity achieved by injecting BoNT-A at different sites of the gracilis muscle. ⋯ The results suggest that BoNT-A injection of the gracilis at sites with a high concentration of MEPs is effective at reducing spasticity. These preliminary findings should be confirmed by larger studies. In the case of long muscles, such as the gracilis, the injection site is important.