Developmental medicine and child neurology
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Dev Med Child Neurol · Mar 2011
Meta AnalysisThe association of genetic polymorphisms with cerebral palsy: a meta-analysis.
The aim of our meta-analysis was to summarize quantitatively the association of genetic polymorphisms with cerebral palsy (CP). ⋯ This meta-analysis demonstrated that CP is associated with the genetic polymorphism IL-6 (rs1800795).
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Dev Med Child Neurol · May 2009
Meta AnalysisExogenous melatonin for sleep problems in individuals with intellectual disability: a meta-analysis.
Recent meta-analyses on melatonin has raised doubts as to whether melatonin is effective in treating sleep problems in people without intellectual disabilities. This is in contrast to results of several trials on melatonin in treating sleep problems in individuals with intellectual disabilities. To investigate the efficacy of melatonin in treating sleep problems in individuals with intellectual disabilities, we performed a meta-analysis of placebo-controlled randomized trials of melatonin in individuals with intellectual disabilities and sleep problems. ⋯ Quality of trials was assessed using the Downs and Black checklist. Nine studies (including a total of 183 individuals with intellectual disabilities) showed that melatonin treatment decreased sleep latency by a mean of 34 minutes (p<0.001), increased total sleep time by a mean of 50 minutes (p<0.001), and significantly decreased the number of wakes per night (p<0.05). Melatonin decreases sleep latency and number of wakes per night, and increases total sleep time in individuals with intellectual disabilities.