Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
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Randomized Controlled Trial Clinical Trial
Effects of intravenous infusion rate of oxytocin on thoracic epidural pressure in parturients undregoing elective cesarean section.
The effects of intravenous oxytocin on thoracic epidural pressure during cesarean section were studied in 90 parturients (American Society of Anesthesiologists physical atatus class I or II) after obtaining informed consent. The subjects were randomized to either a control (control group; n=30), bolus (bolus group; n=30) or drip treatment group (drip group; n=30). The subjects were anesthetized with 11 approximately 12 mg of intrathecal isobaric bupivacaine (0.5%). ⋯ Epidural pressure immediately after placental delivery in the bolus group was higher than in the control group (p<0.0001) and epidural pressure at 5 minutes after fetus delivery in the drip group was higher than in the control group (p=0.0452). There were no significant differences in changes in blood pressure and heart rate among the three groups. We concluded that the increase in epidural pressure with intravenous administration of oxytocin 10 units over 5 minutes was lower than with intravenous administration of oxytocin 10 units over 30 seconds after fetus delivery.
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The aim of this study was to clarify the time course of plasma endothelin-1 levels and platelet counts after elective cesarean section in women with preeclampsia, and to investigate the relationship between them postoperatively. ⋯ Endothelin-1 production is stimulated after cesarean section, which is paralleled with postpartal thrombocytopenia only in patients with preeclampsia.