Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
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Comparative Study Clinical Trial Controlled Clinical Trial
Effect of low-dose ketamine on redistribution hypothermia during spinal anesthesia sedated by propofol.
Mild hypothermia is a common complication during spinal anesthesia and may induce a serious adverse outcome. We investigated the effect of low-dose ketamine infusion on the core temperature during spinal anesthesia sedated by propofol infusion. Twenty patients who were scheduled to undergo spinal anesthesia were assigned to one of two groups: after intrathecal injection of bupivacaine, patients who received infusion of ketamine (0.3 mg/kg/hr) and propofol (initial rate of 10 mg/kg/hr) (KP group), and patients who received infusion of placebo (saline) and propofol (initial rate of 10 mg/kg/hr) (P group). ⋯ The delta CT at 15, 30, 45, and 60 minutes was significantly smaller in the KP group than in the P group. There were no significant differences in the forearm-fingertip temperature gradient between the two groups over the study period. In conclusion, low-dose ketamine administration may confer thermoprotection during spinal anesthesia sedated by propofol.