Medical journal, Armed Forces India
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Med J Armed Forces India · Jan 1994
DOSE RESPONSE RELATIONSHIP OF NEUROMUSCULAR BLOCKADE, INTUBATION CONDITIONS AND CARDIOVASCULAR CHANGES WITH CHANDONIUM IODIDE.
One hundred and forty ASA physical status I and II patients undergoing general or gynaecological surgery were the subjects of this study. Patients were randomly assigned into five groups receiving 100, 150, 180, 200 and 250 µg/kg I. V. of chandonium iodide after induction of general anaesthesia with thiopentone. ⋯ Intubation conditions also improved with increasing doses of chandonium iodide, so that, although intubation was possible in all the patients, grading of good intubation conditions were achieved in 64, 80, 88, 100 and 100% of patients in groups I to V respectively. 200 µg/kg of chandonium iodide produced ideal intubation conditions. Recovery to spontaneous ventilation was rapid and smooth, further facilitated with neuromuscular antagonists. Short lasting increase in heart rate and blood pressure was seen which was neither dose dependent nor outlasting the duration of neuromuscular blockade.