BJOG : an international journal of obstetrics and gynaecology
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To assess whether there is a decrease in endometrial thickness following discontinuation of tamoxifen treatment as measured by ultrasound. ⋯ Median thickness of endometrial thickness significantly reduced within six months following tamoxifen discontinuation, and remained constantly low thereafter. This finding may support use of ultrasonographic imaging for the measurement of tamoxifen's effect on the endometrium of postmenopausal breast cancer patients.
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Randomized Controlled Trial Comparative Study Clinical Trial
A double-blind placebo controlled randomised trial of misoprostol and oxytocin in the management of the third stage of labour.
To compare oral misoprostol 400 microg with intramuscular oxytocin 10 IU in the routine management of the third stage. ⋯ In low risk women oral misoprostol appears to be as effective in minimising blood loss in the third stage of labour as intramuscular oxytocin. Shivering was noted more frequently with misoprostol use, but no other side effects were noted. Misoprostol has great potential for use in the third stage of labour especially in developing countries.
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Randomized Controlled Trial Comparative Study Clinical Trial
The misoprostol third stage of labour study: a randomised controlled comparison between orally administered misoprostol and standard management.
To compare misoprostol with standard oxytocic regimens in the prevention of postpartum haemorrhage. ⋯ Oral misoprostol for the prevention of postpartum haemorrhage was comparable to standard oxytocics. Many side effects were less common with misoprostol but shivering and pyrexia were more common. Larger randomised trials are needed before establishing the equivalence between misoprostol and standard oxytocic drugs in the prevention of postpartum haemorrhage.