BJOG : an international journal of obstetrics and gynaecology
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Randomized Controlled Trial Comparative Study Clinical Trial
A randomised controlled trial of intramuscular syntometrine and intravenous oxytocin in the management of the third stage of labour.
To compare the efficacy and safety of intravenous oxytocin with intramuscular syntometrine in the management of the third stage of labour. ⋯ There are no important clinical differences in the effectiveness of intramuscular syntometrine and intravenous oxytocin for the prevention of postpartum blood loss. Intravenous oxytocin is less likely to cause hypertension.
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To investigate the clinical suspicion that postpartum women are more difficult to anticoagulate with warfarin than non-pregnant women due to the physiological changes in coagulation proteins that persist into the postpartum period. ⋯ Postpartum women require larger doses of warfarin to reach therapeutic international normalised ratio than non-pregnant women. We would recommend the use of a dosing nomogram.