BJOG : an international journal of obstetrics and gynaecology
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Randomized Controlled Trial Clinical Trial
A double-blind randomised controlled trial of laparoscopic uterine nerve ablation for women with chronic pelvic pain.
To determine the effectiveness of laparoscopic uterine nerve ablation (LUNA) for chronic pelvic pain in women with endometriosis and women with no laparoscopic evidence of endometriosis. ⋯ LUNA is effective for dysmenorrhoea in the absence of endometriosis, although there is no evidence of effectiveness of LUNA for non-dysmenorrhoeic chronic pelvic pain or for any type of chronic pelvic pain related to endometriosis.
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Multicenter Study
A prospective study of pregravid oral contraceptive use in relation to fetal growth.
Because oral contraceptives are so widely used, any health consequences may have substantial public health implications. Whether pregravid oral contraceptives could affect subsequent pregnancies has not been adequately studied. The study objectives were to examine whether pregravid oral contraceptive use affects fetal growth and pregnancy hormone levels. ⋯ Pregravid oral contraceptive use is positively associated with fetal growth, and this effect may be mediated through oestriol and progesterone.
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Comparative Study
The safety of ondansetron for nausea and vomiting of pregnancy: a prospective comparative study.
Ondansetron (Zofran) is a drug used for the treatment of nausea and vomiting caused by cancer chemotherapy. Despite the fact that it is not indicated, women are being prescribed this drug for the treatment of nausea and vomiting of pregnancy (NVP). There is a paucity of information on fetal safety for this indication. The objective of this study is to determine whether this drug increases the baseline rate of major malformations. ⋯ This drug does not appear (although the sample size is limited) to be associated with an increased risk for major malformations above baseline.