BJOG : an international journal of obstetrics and gynaecology
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Randomized Controlled Trial
Pharmacokinetic interaction studies of atosiban with labetalol or betamethasone in healthy female volunteers.
In two separate trials, we studied the concomitant administration of atosiban with labetalol and betamethasone to determine any possibility of a clinically relevant pharmacokinetic interaction. ⋯ The co-administration of atosiban with betamethasone or labetalol had no clinically relevant influence on their bioavailability or tolerability.
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Multicenter Study Comparative Study Controlled Clinical Trial
Female sterilisation: a cohort controlled comparative study of ESSURE versus laparoscopic sterilisation.
To compare patient satisfaction, discomfort, procedure time, success rate and adverse events of hysteroscopic (ESSURE, Conceptus Inc, San Carlos, USA) versus laparoscopic sterilisation. ⋯ This study provides evidence that ESSURE can be performed in the majority of women and, when successful, is associated with a greater overall patient satisfaction rate than laparoscopic sterilisation. Women also spend less time in hospital, have better tolerance of the procedure and describe less severe post-operative pain. However, the devices cannot be bilaterally placed in all cases and some women do not tolerate the procedure awake.