BJOG : an international journal of obstetrics and gynaecology
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Randomized Controlled Trial Multicenter Study
Magnesium sulphate given before very-preterm birth to protect infant brain: the randomised controlled PREMAG trial*.
To evaluate whether magnesium sulphate (MgSO(4)) given to women at risk of very-preterm birth would be neuroprotective in preterm newborns and would prevent neonatal mortality and severe white-matter injury (WMI). ⋯ Although our results are inconclusive, improvements of neonatal outcome obtained with MgSO(4) are of potential clinical significance. More research is needed to assess the protective effect of MgSO(4) alone or in combination with other neuroprotective molecules.
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Randomized Controlled Trial Multicenter Study
The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for children at 18 months.
To assess the long-term effects of in utero exposure to magnesium sulphate for children whose mothers had pre-eclampsia. ⋯ The lower risk of eclampsia following prophylaxis with magnesium sulphate was not associated with a clear difference in the risk of death or disability for children at 18 months.
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Multicenter Study
Internal iliac artery ligation for arresting postpartum haemorrhage.
To study the role of internal iliac artery ligation (IIAL) in arresting and preventing postpartum haemorrhage (PPH). ⋯ IIAL is useful in the treatment and prevention of PPH from any cause. Early resort to IIAL effectively prevents hysterectomy in women with atonic PPH. In traumatic PPH, IIAL facilitates hysterectomy or repair as indicated and prevents reactionary haemorrhage.
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The aim of this study was to review systematically the available evidence on studies in humans on the effects of low-moderate levels of prenatal alcohol consumption (up to 10.4 UK units or 83 g/week) compared with consumption of no alcohol on pregnancy outcome. ⋯ This systematic review found no convincing evidence of adverse effects of prenatal alcohol exposure at low-moderate levels of exposure. However, weaknesses in the evidence preclude the conclusion that drinking at these levels during pregnancy is safe.