BJOG : an international journal of obstetrics and gynaecology
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Randomized Controlled Trial Multicenter Study
Intramuscular oxytocin versus Syntometrine® versus carbetocin for prevention of primary postpartum haemorrhage after vaginal birth: a randomised double-blinded clinical trial of effectiveness, side effects and quality of life.
To compare intramuscular oxytocin, Syntometrine® and carbetocin for prevention of postpartum haemorrhage after vaginal birth. ⋯ IM carbetocin does not reduce additional uterotonic use compared with IM Syntometrine or oxytocin.
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Randomized Controlled Trial
Virtual reality for acute pain in outpatient hysteroscopy: a randomised controlled trial.
To evaluate the effectiveness of virtual reality as a distraction technique in the management of acute pain and anxiety during outpatient hysteroscopy. ⋯ Virtual reality can be used as a part of a multimodal strategy to reduce acute pain and anxiety in patients undergoing outpatient hysteroscopy.
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Randomized Controlled Trial Multicenter Study
An economic evaluation of tranexamic acid to prevent postpartum haemorrhage in women with vaginal delivery: the randomised controlled TRAAP trial.
To estimate the cost-effectiveness of tranexamic acid (TXA) use to prevent postpartum haemorrhage. ⋯ Tranexamic acid at vaginal delivery reduces both costs and bleeding events 3 times out of 4.
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Randomized Controlled Trial
Association of the eukaryotic vaginal virome with prophylactic antibiotic exposure and reproductive outcomes in a subfertile population undergoing in vitro fertilisation: a prospective exploratory study.
The objective of this study was to use high-throughput sequencing to describe the vaginal eukaryotic DNA virome in patients undergoing in vitro fertilisation (IVF) to examine associations between the vaginal virome, antibiotic exposure and IVF outcomes. ⋯ Higher viral diversity is associated with prophylactic antibiotic exposure in subfertile women undergoing IVF.
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Randomized Controlled Trial
Triaging women with human papillomavirus infection and normal cytology or low-grade dyskaryosis: evidence from 10-year follow up of the ARTISTIC trial cohort.
To estimate long-term cervical intraepithelial neoplasia grade 3 (CIN3) risks associated with different triage strategies for human papillomavirus positive (HPV+) women with a view to reducing unnecessary referrals. ⋯ Cervical screening would be better for women and cheaper for the NHS if women with HPV and normal to low-grade cytology were retested after a year or two when many infections will have cleared.