BJOG : an international journal of obstetrics and gynaecology
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Randomized Controlled Trial
Transdermal clonidine in the treatment of severe hyperemesis. A pilot randomised control trial: CLONEMESI.
To study the efficacy of transdermal clonidine in the treatment of severe refractory hyperemesis gravidarum (HG), the most severe illness of pregnancy. ⋯ This preliminary RCT demonstrates the efficacy of transdermal clonidine in the treatment of severe HG, leading to a significant reduction of symptoms and reducing the need for other supportive measures and medications.
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Comparative Study Observational Study
Maternal depression, antidepressant prescriptions, and congenital anomaly risk in offspring: a population-based cohort study.
To estimate risks of major congenital anomaly (MCA) among children of mothers prescribed antidepressants during early pregnancy or diagnosed with depression but without antidepressant prescriptions. ⋯ Overall MCA risk did not increase with maternal depression or with antidepressant prescriptions. Paroxetine was associated with increases of heart anomalies, although this could represent a chance finding from a large number of comparisons undertaken.
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To evaluate whether defective placentation disorders, i.e. pre-eclampsia, stillbirth, small for gestational age (SGA), and spontaneous preterm birth, are associated with risk of retained placenta. ⋯ Defective placentation disorders are associated with an increased risk of retained placenta. Whether these relationships indicate a common pathophysiology remains to be investigated.
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Comparative Study
Management and outcomes of acute appendicitis in pregnancy-population-based study of over 7000 cases.
To compare outcomes and management practices among pregnant and nonpregnant women with acute appendicitis. ⋯ Compared with nonpregnant women, pregnant women with acute appendicitis have higher rates of adverse outcomes. Conservative management should be avoided given the serious risk of adverse outcomes in pregnancy.