BJOG : an international journal of obstetrics and gynaecology
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Randomized Controlled Trial
Association of the eukaryotic vaginal virome with prophylactic antibiotic exposure and reproductive outcomes in a subfertile population undergoing in vitro fertilisation: a prospective exploratory study.
The objective of this study was to use high-throughput sequencing to describe the vaginal eukaryotic DNA virome in patients undergoing in vitro fertilisation (IVF) to examine associations between the vaginal virome, antibiotic exposure and IVF outcomes. ⋯ Higher viral diversity is associated with prophylactic antibiotic exposure in subfertile women undergoing IVF.
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Randomized Controlled Trial
Triaging women with human papillomavirus infection and normal cytology or low-grade dyskaryosis: evidence from 10-year follow up of the ARTISTIC trial cohort.
To estimate long-term cervical intraepithelial neoplasia grade 3 (CIN3) risks associated with different triage strategies for human papillomavirus positive (HPV+) women with a view to reducing unnecessary referrals. ⋯ Cervical screening would be better for women and cheaper for the NHS if women with HPV and normal to low-grade cytology were retested after a year or two when many infections will have cleared.
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The QUiPP algorithm combines cervical length, quantitative fetal fibronectin (qfFN) and medical history to quantify risk of preterm birth. We assessed the utility of QUiPP to inform preterm birth prevention treatment decisions. ⋯ Independent study finds that the QUiPP algorithm could lead to substantial increases in treatment without evidence of benefit.
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To estimate incidence, trends over time, and risk factors for massive blood transfusions in obstetric patients. A secondary aim was to evaluate transfusion ratios in relation to massive transfusion. ⋯ Risk of massive blood transfusion in obstetric patients increases with placental complications and prior caesarean section.
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Meta Analysis
The safety of oral fluconazole during the first trimester of pregnancy: a systematic review and meta-analysis.
Oral fluconazole is used to treat vulvovaginal candidiasis during pregnancy. However, there are concerns regarding the pregnancy outcomes following exposure to fluconazole. ⋯ Oral fluconazole during the first trimester of pregnancy may be associated with unfavourable pregnancy outcomes.