Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova
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Fiziol Zh SSSR Im I M Sechenova · Jul 1989
Comparative Study[Insulin and glucocorticoid binding by blood cell receptors after hydrocortisone administration in rabbits].
Repeated i.v. administration of hydrocortisone (10 mg/kg) revealed an increase in the resistance against insulin although endogenous corticosterone was decreased in 33 male rabbits. The insulin- and dexamethasone-binding receptors of erythrocytes and mononuclear leucocytes. changed after 3-7 hydrocortisone injections, the binding increasing for insulin and diminishing for dexamethasone.
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Fiziol Zh SSSR Im I M Sechenova · Dec 1986
[Various morphofunctional properties of erythrocytes of animals acclimatized to heat].
The effect of prolonged experimental heat exposure on morpho-functional characteristics; of animal erythrocytes involved formation of a new erythrocyte population with increased cell diameter, volume and hemoglobin content, enhanced electrophoretic velocity and resistance against various hemolytic factors.
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Fiziol Zh SSSR Im I M Sechenova · Aug 1982
[Conjunct changes in the resistance and engorgement of the cerebral vessels in shifts in the blood gas composition].
In anesthetized cats, under perfusion and with constant volume of the hemodynamically isolated brain, hypercapnia and hypoxia led to a decrease of cerebral vessels resistance and to a reduction of the brain blood flow, whereas a decrease in the PCO2 and an increase in the PO2 in the blood exerted on opposite effect. The different responses of the vessels had some similar features in respect to threshold changes of the PCO2 and PO2, to potentiation of effects of both parts of the brain vascular system on increased shifts of the blood gas tension, to greater sensitivity of both parts to PCO2 changes, to effect of the blood gas tension on reactivity of both parts to noradrenaline. The authors suggest a possibility of alterations of the filter-absorption interrelationships in the brain due to different responses of arterial and venous vessels to changes of the blood gas tension.
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Fiziol Zh SSSR Im I M Sechenova · Jan 1982
[Effect of systemic arterial and venous pressures on blood volume in the cerebral vessels].
In rabbit chest-head preparation with largely exposed brain, the cerebral volume (CV) and the cerebral blood volume (CBV) were continuously recorded number conditions of controlled alterations of the systemic arterial and venous pressures (SAP and SVP resp.). The obtained relationships were linear and described by the equations as follows: delta CV = 0.0028 SAP; delta CBV = 0.0013 SAP; delta CV = 0.028 SVP; delta CBV = 0.013 SVP; they show the effect of the SVP changes to be nearly ten times greater than that of the SAP. Half of the increase in CV was caused by the CBV increase and the other half - by tissue hydration under particular conditions of the experiments. The data obtained bear on the effects of the systemic circulation on brain oedema development.