Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science
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Contemp Top Lab Anim Sci · Sep 2005
Comparative StudyComparison of tympanic, transponder, and noncontact infrared laser thermometry with rectal thermometry in strain 13 guinea pigs (Cavia porcellus).
The purpose of this experiment was to assess the practicality, ease, and reliability of using tympanic, transponder, and noncontact infrared laser thermometry versus rectal thermometry in strain 13 guinea pigs. Body temperatures were measured by all four methods within each animal over 10 min, and three sets of measurements were taken over 2 days. Each method was compared for agreement over time and agreement with the rectal temperature of each animal. ⋯ Although the mean temperatures from the transponder and tympanic thermometers were not significantly different from the rectal temperatures, only the transponder method was in close agreement with the rectal method. The tympanic and noncontact infrared laser methods had poor agreement with the rectal method. These study results suggest that transponder thermometry is an easy and accurate alternative to rectal thermometry in strain 13 guinea pigs.
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Contemp Top Lab Anim Sci · Sep 2005
Comparative StudyA comparison of target-controlled infusion versus volatile inhalant anesthesia for heart rate, respiratory rate, and recovery time in a rat model.
We conducted this study to determine whether heart rate, respiratory rate, and recovery time differed significantly between rats receiving target-controlled infusion (TCI) and those under volatile inhalant anesthesia. TCI rats received intravenous propofol at an average effect site concentration of 11.3 microg/ml or propofol plus ketamine (5 mg/ml of propofol) at an average effect site concentration of 8.7 microg/ml. Inhalant anesthesia rats received isoflurane (average, 1.8%) delivered in medical-grade air. ⋯ Recovery time was longer for both TCI regimens compared with isoflurane (P <0.001). Once venous access was accomplished, TCI anesthesia with propofol or propofol combined with a low dose of ketamine was comparable to an isoflurane inhalant regimen in ease of administration and control of the anesthetic event when used in rats for procedures of 1-h duration. Respiratory rate was increased and recovery time was longer for rats receiving the TCI regimens.