Advances in wound care
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Advances in wound care · Sep 2013
ReviewDisclosure of the Culprits: Macrophages-Versatile Regulators of Wound Healing.
Macrophages are invariably present and tightly regulate all phases of adult wound healing, including inflammation, granulation tissue formation, and matrix deposition with the unavoidable outcome of scar formation. In response to environmental cues, macrophages mount a "classical" pro-inflammatory M1 activation as opposed to the "alternative" M2 phenotype, with wound macrophages having long been viewed as M2 macrophages. ⋯ If characterized in sufficient detail, distinct macrophage subsets and their impaired functions provide ideal targets for improving wound healing.