European journal of applied physiology
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Eur. J. Appl. Physiol. · May 2000
Cytokines and cell adhesion molecules associated with high-intensity eccentric exercise.
Unaccustomed, eccentrically biased exercise induces trauma to muscle and/or connective tissue. Tissue damage activates an acute inflammatory response. Inflammation requires the effective interaction of different physiological and biological systems. ⋯ Results were analyzed using a repeated-measures analysis of variance (P = 0.05). Compared to baseline values, IL-1beta was reduced (P = 0.03) at 6, 24, and 96-144 h after exercise; IL-6 was elevated (P = 0.01) at 12, 24, and 72 h after exercise; IL-10 was elevated (P = 0.009) between 72 and 144 h after exercise; M-CSF was elevated (P = 0.005) at 12 and 48-144 h after exercise; and P-selectin was reduced (P = 0.01) between 24 and 144 h after exercise. It is concluded that when high-intensity eccentric exercise is compared to strenuous endurance exercise, post-exercise changes in cytokines do occur, but they are generally of a smaller magnitude, and occur at a later time period after the termination of exercise.